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The legumain protease-activated auristatin prodrugs suppress tumor growth and metastasis without toxicity

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It is used as a precursor to help the body make NAD+ efficiently.* Apigenin- flavonoid found in plants that has been shown to reduce NAD+ waste by inhibiting the CD38 enzyme.* TMG (Trimethylglycine / Betaine)- An amino acid derivative that aids in the process of NAD+ recycling and may help maintain healthy homocysteine levels.* Lutein + Zeaxanthin (Lutemax)- Carotenoids that can help protect the skin from oxidative stress and UV exposure

Reproduction 159:105113 Tateishi K, Higuchi F, Miller JJ, Koerner MVA, Lelic N, Shankar GM, Tanaka S, Fisher DE, Batchelor TT, Iafrate AJ et al (2017) The alkylating chemotherapeutic temozolomide induces metabolic stress in IDH1-mutant cancers and potentiates NAD(+) depletion-mediated cytotoxicity

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