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doi: 10.1186/s40168-017-0253-y 152 XiangX.PangH.MaT.DuF.LiL.HuangJ.et al

Ikeno H, Tochio T, Tanaka H, Nakata S

Although its efficacy is lower than methotrexate and cyclosporine, apremilasts favorable safety profile, particularly its low hepatotoxicity risk, makes it a valuable option for patients who require long-term systemic therapy and cannot tolerate immunosuppressants (Papp et al

In animal studies, both routes have shown biological activity, but injection delivers the peptide systemically with greater predictability