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Comparative Benefits and Harms of Antidepressant, Psychological, Complementary, and Exercise Treatments for Major Depression: An Evidence Report for a Clinical Practice Guideline From the American College of Physicians

doi: 10.1016/s0891-5849(02)01084-5

3) is the maintenance of tissue homoeostasis at all the levels of CNS organisation, from molecular (ions, metabolites, and neurotransmitters, etc.), to network (regulation of synaptic connectivity), to organ (formation and maintenance of bloodbrain barrier and glymphatic clearance system) and systemic (chemosensing blood oxygen, Na + , CO 2 or glucose)

Most people begin to notice changes in their skin hydration and joint comfort within 4 to 6 weeks of consistent use

Because of this, oral versions are typically sold "for research purposes only" and are not intended for everyday consumer use