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Of the patients with severe elevation in liver enzymes, n=19 (95%) occurred while critically ill in the ICU

[Google Scholar] 76.Yim W, Takemura K, Zhou J, Zhou J, Jin Z, Borum RM, Xu M, Cheng Y, He T and Penny W, ACS Nano, 2021, 16, 683693

Myocardin-related transcription factor A (MRTF-A) contributes to acute kidney injury by regulating macrophage ROS production

The metabolic demands of infiltrating B cells within this intrarenal nichecharacterized by hypoxia and nutrient limitationare likely met by the same glycolytic reprogramming observed in secondary lymphoid organs, enabling local autoantibody production and contributing directly to tissue injury (125, 126)

Specifically, BBR blocks autophagy in HSCs and downregulates autophagy protein 5 expression, which leads to HSC death (90)