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It has been shown that the SCFatrogin-1 complex serves a crucial role in the regulation and inhibition of calmodulin phosphatase activity through the ubiquitination-dependent protein degradation pathway

Despite the identification of many potential targets of antioxidant therapy, and abundant pre-clinical data, few antioxidant agents have undergone formal trials to assess clinical benefit in COPD

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Tabe Y, Saitoh K, Yamatani K, Yang H, Jacamo R, Ma H, Ruvolo V, Zhang Q, Kuruvilla V, Baran N, Imoto J, Ikeo K, Moriya K, Murakami-Tonami Y, Suzuki K, Miida T, Andreeff M , Vellano CP, Marszalek JR, Konopleva M