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doi: 10.1186/s40795-025-01004-6 9

Dopamine and depression

These psychomotor effects of cannabis are mainly attributed to the 9 -tetrahydrocan-nabinol ( 9 -THC), the major psychoactive constituent in Cannabis sativa plant by acting on the cannabinoid (CB1) receptor that is highly expressed in the basal ganglia, the cerebral cortex and the cerebellum (Ameri, 1999