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Let me break it down clearly

PubMed (PMID: 10482990) Manning MC, Chou DK, Murphy BM, et al

That is what their reference to "immunogenicity" means

Sarcopenic obesity Finally, the confluence of ageing and obesity epidemics has resulted in the concomitant presence of accelerated sarcopenia and obesity, termed sarcopenic obesity, which seems to be associated with a risk synergistic with those of the individual entities [12]