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Cleavage of GCLC occurs at Asp 499 within the sequence AVVD 499 G, which lies upstream of Cys 553 that is thought to be important for association with GCLM (Franklin et al., 2002)

It also promotes sun tanning, forms freckles and age spots, and causes uneven pigment in some people

Collagen peptides have more human data on knee osteoarthritis symptoms, but even there, results are mixed and effect sizes are often modest

Curr Biol 10(11):640648 Hedayati N, Safari MH, Milasi YE, Kahkesh S, Farahani N, Khoshnazar SM et al (2025) Modulation of the PI3K/Akt signaling pathway by resveratrol in cancer: molecular mechanisms and therapeutic opportunity