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Factors such as genetics, lifestyle and environment also play a considerable role

The cation of 7 is NH 2

Since the symptoms of COVID-19 are mainly presented in the respiratory system, in this review, we aimed to summarize the studies related to pulmonary delivery of drugs used and tested in vitro, in animal, or in trials for COVID-19 pandemic

An accumulation of TCA intermediates may subsequently have an impact on the macrophage phenotype, e.g., by contributing to a pro-inflammatory phenotype [e.g., as shown for succinate (Tannahill et al., 2013) and oxaloacetate (Di Gioia et al., 2020)], fatty acid synthesis for membrane production or pro-inflammatory fatty acid-derivatives as prostaglandin [for citrate (Infantino et al., 2011)] or by triggering innate immune memory [for fumarate ( 4.2.1 TCA intermediate accumulation in M1 and trained macrophages More specifically, increased glutamine uptake in LPS-stimulated macrophages triggered the accumulation of succinate, which stabilized HIF1 and thereby increased the expression of the inflammatory mediator IL-1 (Tannahill et al., 2013)

Conversely, the FXR agonist GW4064 or -hydroxybutyrate elevated FXR and suppressed PPAR