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For example, to reduce immunogenicity of therapeutic mouse monoclonal antibodies, either the mouse Fc fragment or the whole antibody constant regions (CH1CH3) were replaced with the human counterparts by means of genetic manipulations, whereas the mouse Fab or Fv (VH-VL) fragments retained the original epitope specificity

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593,598,599 SIRT3 protects against mitochondrial damage in the kidneys by attenuating oxidative stress, inhibiting inflammation and inducing autophagy through regulation of the AMPK/mTOR pathway