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Studies have mainly explored the regulatory effects of AS-IV on fibrosis from the perspectives of experimental animal models at the cellular, molecular and genetic levels, with most only focusing on single drug components and large-sample placebo-controlled, randomized and standardized double-blind experimental data regarding TCM treatments awaiting further investigation (10,14)

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Future studies should prioritize: in vivo evaluation in infected wound models to assess healing efficacy and safety, mechanistic investigations into antimicrobial and antibiofilm pathways, extended release studies beyond 24 h to correlate with chronic wound healing timelines, and formulation optimization for scalability and regulatory compliance

J Clin Med 9(4):1034 Demers LM (2004) Thyroid disease: pathophysiology and diagnosis