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FIGURE 10 4.1 The main takeaways Our conclusions can be viewed in the light of two different scenarios: (1) how can we achieve better target-site coverage with existing sprays, and (2) what are the insights here for the design of improved spray devices in the future

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CBS is a highly regulated enzyme, with S-adenosylmethionine acting as an allosteric activator that increases CBS activity as well as stabilizing the enzyme (and thus increasing its concentration) when Met is abundant (Janosik et al

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Emerging evidence suggests a bidirectional relationship between gut health and brain function, often referred to as the gut-brain axis. Intestinal I/R injury, as a form of acute gut stress, has been implicated in triggering systemic inflammatory responses that extend beyond the gut, to impact distant organs, including the brain (Osadchiy et al., 2019)