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Another naturally occurring sphingolipid, sphingosine-1-phosphate, has been shown in vitro to modulate the expression of GPX4 and FPN1, and TFRC, which may contribute to reduce radiation-induced ferroptosis in KGN cells (Zhao et al., 2023)

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And melanoma, particularly brain metastases with poor prognosis, exhibits increased dependency on above-mentioned acetate, a weakness specific to BRAF-mutant tumors (Kamphorst et al., 2014

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