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Additionally, a negative correlation between complex II activity and oxidative stress measures has been reported in BD patients during depressive episodes, suggesting that mitochondrial oxidative stress related mitochondrial dysfunction may contribute to bipolar depression [50]

RT-qPCR validation demonstrated that mRNA levels of mt-Nd1 , mt-Nd4 , mt-Nd5 , mt-Nd6 , and mt-Co2 were significantly elevated in Se/LDH@PEG-M-treated cells compared to the LPS controls (Fig

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