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UVR-induced DNA damage and alterations in the extracellular matrix (ECM) disrupt homeostasis and trigger cellular stress, leading to the activation of inflammatory responses in the skin as shown in Figure 2

10.1074/jbc.M413224200 [DOI] [PMC free article] [PubMed] [Google Scholar] Cannon JR, Tapias VM, Na HM, Honick AS, Drolet RE, Greenamyre JT, 2009

In the previous study, food-derived glutathione disulfide was, however, detected in liver and blood red cell of mice

While TUDCA is generally well-tolerated and backed by human studies in specific contexts (e.g., liver disease, insulin sensitivity), there are several populations who should avoid it

In COVID-19, infection activates inflammatory and coagulant responses, causing reduced lung perfusion