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Psychiatry 88 , 159168 (2020)

However, terminally differentiated plasma cells, known as long-lived plasma cells (LLPCs), no longer express CD19 (94)

Further evidence for the involvement of miRNAs in the mechanism of ECT comes from a study involving 64 patients with TRD: At baseline, expression of miRNA-223-3p was significantly lower in responders compared to non-responders and demonstrated moderate predictive capacity for ECT response (AUC = 0.76, 95% CI = 0.60.91) [28]

Therefore, the Nrf2 signaling pathway literally helps the body to heal itself

This creates a beneficial cycle: better gut function supports better brain function, which in turn may improve gut-brain signaling