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1), while the sugar moiety, through its hydroxyl groups, is close to the main chain carbonyls of G323 and R322 in one conformation and with the analogous groups of G437 and Q440 occupying the hydrophilic portion of subpocket A in the other conformation

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Serious allergic reactions happen in less than 1% of cases but can include throat swelling, severe rash, and breathing difficulty requiring immediate emergency care

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