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Interestingly, fumarate accumulation-mediated succination of LYN (tyrosine protein kinase) and consequent inhibition of the B-cell antigen receptor signalling, could affect the progression of B cell leukaemia and lymphomas [113, 114]

Additionally, in the context of lowered ATP production, which is a hallmark of mitochondrial diseases, it is important to note that NAC, essentially only being a form of cysteine, will require 2 ATP molecules to be converted to glutathione