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2) May Be Toxic to Some Neurons Though most studies have shown a positive effect of GDNF on neuron health, neurons vary across brain regions in how they respond to this factor

AVP hnRNA responses are slower, peaking at 11.5-fold increase by 2 hours, followed by a prolonged elevation of AVP mRNA levels from 4 hours onwards (193)

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Whether ATII cells express ORs to detect environmental factors and whether ORs like OR51B5 have protective or harmful effects remain to be investigated in the future