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Alterations in kidney metabolism lead to abnormal expression of signaling molecules and activation of pathways, inducing oxidative stress-related cellular damage, inflammatory responses, apoptosis, and autophagy irregularities, culminating in renal fibrosis and insufficiency

PARP enzyme de novo synthesis of protein-free poly(ADP-ribose)

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Since these cells are the most resistant cells to chemotherapy and radiotherapy within the tumor [17], they are considered as responsible for tumor relapse [15]