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GO (Gene Ontology) analyses were conducted using the R package clusterProfile (version 3.14.3)

Unbound iron enters the cardiomyocytes through the L-type calcium channels ( The fact that cardiomyocyte iron overload is a storage problem and not an infiltrative process indicates that iron can be removed to reverse cardiac iron overload and associated damage ( Molecular mechanism of myocardial injury caused by cardiac iron overload in thalassemia Iron overload is a common feature in patients with -thalassemia, but the molecular mechanism of cardiac damage caused by iron overload in thalassemia is poorly understood

Acknowledging this debate is essential for a balanced understanding of brain energetics and for guiding the future research needed to elucidate the precise metabolic interactions that sustain brain function

516 Most of the mature ZnT8A responses target the C-terminal region of the protein, while only 10% recognize the N-terminal region