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Notably, in most countries PAC is freely sold as an OTC drug, raising the risk of unintentional abuse and increased adverse effects ( No answer can be given to the above open questions because PAC efficacy/adverse effects, unlike most of the drugs repositioned for COVID-19 therapy, have not yet been evaluated in controlled clinical trials or analyzed through retrospective analyses

3 , e1044 (2023)

Hence, other treatments have been tested

Research shows around 85% of the caffeine in gum absorbs within 5 to 15 minutes, compared to 20 to 45 minutes for capsules and drinks

doi: 10.1530/REP-16-0312 192 KapoorAMatthewsSG