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Based on the phenomena directly observed in the OA model, the mechanisms verified in other chronic inflammatory/degenerative diseases [such as rheumatoid arthritis (RA)], and reasonable inferences based on the cross-linkages of molecular pathways, we propose a hypothetical framework, suggesting that the gut microbiota-ferroptosis axis ma contribute to the progression of OA and explore the therapeutic potential of synergistic intervention measures targeting this axis

Enzymatic proteins are involved in the protective mechanism of an organism

Prebiotic supplementation modulates selective effects of stress on behavior and brain metabolome in aged mice

However, noticeable effects like improved sleep typically appear within 1-2 weeks, while body composition changes usually become apparent around weeks 6-8

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