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In experimental animal models, FOXO4-DRI preferentially targets senescent cells while largely sparing healthy cells, although its safety and selectivity in humans remain unknown

The bacterial changes thus resulting could weaken the gut barrier and facilitate the translocation of harmful bacteria from the gut to the blood

Mitochondrial toxins including MPTP and rotenone can induce PD-like symptoms, confirming a direct association between mitochondrial function and PD (119)

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