2.6 Patients 2.6.1 Patient selection and study design Patients were enrolled in a prospective, investigator-initiated, non-randomized, multicenter, open-label study designed to evaluate in part A the safety and efficacy of DARA monotherapy in individuals with relapsed/refractory MM (RRMM) ( PB and BM samples from patients treated with DARA monotherapy in part A of the clinical study were collected at baseline, prior to initiation of DARA monotherapy, and at the time of DARA treatment failure (defined as disease progression [PD] during the first cycle of treatment, less than minimal response after the second treatment cycle, or less than partial response [PR] after the third treatment cycle), or in case of PD after an initial response (PR or better) for evaluation of adenosine (ADO) and inosine (INO) levels
Cultures were grown until logarithmic growth in 35 ml 7H9-0.05% Tween-80-ADC supplemented with or without AdoCbl
Jr, Loch-Caruso, R
By inhibiting NNMT, 5-Amino-1MQ is studied for its ability to alter adipocyte metabolism in a direction associated with reduced fat accumulation and improved metabolic handling of nutrients
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