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Ecotoxicology 29 , 14621475

The way the double-stapled and di-alkyne stapled peptides avoid off-target toxicities is not clear

Because they block vocal fold closure and cause impairment to vocal fold vibration, they produce varying degrees of impairing hoarseness

Indications: Guanethidine is no longer available in the USA due to lack of availability, but is available in the UK (wikipedia) Was used for severe cases of hypertension, either alone or as an adjunct drug Contraindications: Guanethidine can cause a hypertensive crisis in patients with pheochromocytoma due to the release of catecholamines (tyramine like action)