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Evidence level is high

Renal, Liver, and Heart Histology The same scoring system as in the previous studies [12,13,14,15,16,20,22,23,24] was used to grade renal (i.e., the degeneration of Bowmans space and glomeruli, degeneration of the proximal and distal tubules, vascular congestion, and interstitial edema), liver (i.e., vacuolization of hepatocytes and pyknotic hepatocyte nuclei, activation of Kupffer cells, and enlargement of sinusoids) and heart (i.e., dilatation and congestion of blood vessels within the myocardium and coronary arteries) histology

g, common Col-0 27C 2h and Col-0 37C 24h

For the microscopy quantification, ordinary one-way ANOVA was used

Two case reports suggest that neonates and children have a reduced propensity to toxicity following paracetamol overdose due to differences in metabolism [50, 51]