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In contrast, probiotic intervention antagonizes ferroptosis through mechanisms such as reducing inflammation, repairing intestinal barrier, releasing antimicrobial peptides (cAMPs), regulating iron overload, and inhibiting lipid peroxidation (182, 183), thereby ameliorating the pathological phenotype of IBD ( Figure 3 )

DHETs are promising markers of advanced liver fibrosis, and EPHX1 and EET metabolism are novel therapeutic targets for liver fibrosis

This rate typically stabilizes at around 140 mL/min/1.73 m 2 until approximately 30 years of age

Through precise modular design, each modification step aims to optimize their delivery efficiency, with the ultimate goal of transforming them into a next-generation targeted therapeutic tool capable of overcoming the lack of targeting specificity of traditional drugs and reducing systemic side effects