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It will be difficult to identify rare, highly penetrant alleles in novel genes using traditional casecontrol designs because the requisite sample size to detect rare variants is much greater than aggregated cohorts assembled for GWAS

Structural basis for gluten intolerance in celiac sprue

In theory, direct PKA-driven activation of uncoupling proteins may accelerate mitochondrial fat oxidation

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Ruben Rodriguez et al., this method is associated with a mortality rate of 11.4%, a reoperation rate of 12.6%, and a postoperative percutaneous drainage rate of 29.9%