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Marangell LB, Bauer MS, Dennehy EB, et al

Long-term follow-up studies, with samples taken before and after reducing harmful exposures or targeted therapy, can show if exposure-related molecular changes return to normal

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doi:10.1016/j.jacc.2017.10.064 78

A typical titration might start at 0.5 mg per week, increase to 2 mg, and eventually reach doses of 8 mg or 12 mg depending on your providers recommendation