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10.1097/j.pain.0000000000002005 140

Whereas, further rise in the ROS level is accompanied with down regulation of cellular antioxidant defense systems in tumor malignancy through various molecular targets including nuclear factor kappa-light-chain-enhancer of activated B cells (NF-B) and nuclear respiratory factor 2 (Nrf2) [6, 7]

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Importantly, we showed that in vitro the SSRP1-SPT16 complex is able to interact with histone H1 and that SSRP1 retains the ability to interact with it even in the absence of SPT16 (Fig