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doi: 10.1021/acsnano.6b02231 215 LeeSHanHKooHNaJHYoonHYLeeKEet al

2025;6:1002337 DOI: Received: July 01, 2025 Accepted: September 08, 2025 Published: September 23, 2025 Academic Editor: Luca Falzone, University of Catania, Italy The article belongs to the special issue Predictive and Prognostic Biomarkers in Cancer: Towards the Precision Medicine Era Microsatellite-stable metastatic colorectal cancer (MSS mCRC) is currently treated with chemotherapy and targeted agents based on RAS and BRAF mutational status

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Among the regulatory pathways, ferroptosis is the most specific form, Due to the accumulation of intracellular iron ions, lipid peroxidation reaction occurs ( The cystine-GSH-GPX4 axis is a major pathway against ferroptosis in mammals ( Intracellular GSH levels are much higher than extracellular GSH levels, thus, they can participate in REDOX reactive drug delivery and are associated with tumor drug resistance ( 2.2 Phospholipid metabolism pathway Increased lipid peroxidation is a classic feature of.ferroptosis As early as the 1950s, it was reported that selenium, vitamin E and cysteine have certain inhibitory effects on lipid peroxidation

Le NH, Kim CS, Park T, Park JHY, Sung MK, Lee DG, et al