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Sleeping fewer than six hours per night reduces glutathione synthesis and impairs the glymphatic clearance system that depends on it

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As cited above, the amino acid cysteine is a rate-limiting factor for GSH synthesis, and a variety of both clinical trials and in-vitro/in-vivo data suggest that supplying cysteine as NAC is an effective strategy for enhancing GSH production and intracellular cysteine.Intravenous NAC has been utilized for some time to treat acetaminophen and non-acetaminophen induced acute liver failure by restoring the concentration of GSH, and has been found to be safe and effective

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Keeping our patients healthy and out of the surgeons chair is not just a matter of encouraging good nutrition any more