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Investigations reviewed here assessed whether switching to e-cigarettes present less risk than smoking: 1) compare the constituents of the aerosol from e-cigarettes to cigarette smoke, 2) examine the toxicity of aerosols in vitro using tissue culture approaches and in vivo using animal studies, 3) measure HPHC levels in blood and urine from individuals who switch to e-cigarettes and compare them with values in adult smokers, and 4) compare clinical biomarkers of exposure that are known risk factors for smoking-related diseases in individuals who switch to e-cigarettes and those who continue to smoke cigarettes

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Others had a short-term plan to make a quick buck, but Lord and Newns were playing a longer game