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The body has fully adapted to that concentration, and adding more will produce a predictable increase rather than an unpredictable spike

It is homeostatically controlled, both inside the cell and outside and often attains millimolar levels inside cells, which makes it one of the most highly concentra

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Pharmacol Rev 65(1):315499 Wilson ID, Nicholson JK (2014) The modulation of drug efficacy and toxicity by the gut microbiome