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Furthermore, miR-128-3p overexpression effectively mitigated the detrimental impact of Era-induced ferroptosis on mitochondrial morphology (Fig

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Overexpressed mirna: actively promotes drug resistance Some miRNAs are abnormally overexpressed in ovarian cancer, promoting cisplatin resistance by suppressing tumor suppressor genes or drug resistance-related pathways, which is the opposite of their traditional tumor suppressor function

Moreover, the use of statins inhibits HMGCR, leading to inactivation of GPX4 and the increase in ferroptosis occurrence overall (59)