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In preclinical models, chimeric antigen receptor (CAR)-macrophages (CAR-M) targeting the urokinase plasminogen activator receptor (uPAR), a cell-surface receptor upregulated in HSCs in cirrhotic human livers, demonstrated efficacy in reducing liver fibrosis (180)

Deferiprone (also known as ferriprox) is an orally active, brain-permeable drug

officinalis roots and rhizomes reduced the number of seizures of PTZ-induced epileptic rats, reduced the seizure time, and noticeably reduced the expression of the GABA uptake transporter GAT-1 in the hippocampus of epileptic rats

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