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For example, the RFD directs DNMT1 to replicate DNA, while the CXXC domain recognizes and binds DNA containing unmethylated CpG sites

Am J Neuroradiol 32 , 633636 (2011)

However, some mild issues like nausea, stomach discomfort, or a temporary headache can occur

Pure speculation based on experiments with heavy water suggests that histidine may be able to trap deuterium in its imidazole ring, and copper may serve as a catalyst for this by inducing proton currents