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DOI: 10.1183/1393003.congress-2017.OA3400 *Phase 2 result of Pamrevlumab

This work demonstrates the potential of flow synthesis for rapidly producing macrocyclic proteins, with a stabilized transient binding pocket and enhanced affinity for a confirmation-specific ligand screening, thereby showcasing the refinement of protein activity through strategic sequence optimization

Deshpande, I

The protein-ligand complexes were solvated in a TIP3P water box 53 with periodic boundary conditions

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