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IJMS 21, 3293

Endothelial cell dysfunction may reduce nitric oxide bioavailability and increase reactive oxygen species production, leading to impaired ocular hemodynamics (97), whereas reactive oxygen species can induce cellular senescence and apoptosis (98), which may ultimately lead to optic nerve cell apoptosis, exacerbating optic nerve damage and further exacerbating the progression of glaucoma

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A previous study indicated that one site of mold colonization was the gastrointestinal tract that was ascertained by treatment with the antifungal drug nystatin, which is not absorbed from the gastrointestinal tract