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Hydroxocobalamin, the form most commonly used in the UK, may cause: Injection site reactions (pain, redness, or swelling) Temporary reddish discolouration of urine Rarely, hypersensitivity reactions Very rarely, hypokalaemia in severely deficient patients when treatment is initiated (potassium levels should be monitored in severe deficiency) B12 injections are considered very safe, with no upper tolerable limit established, as excess B12 is excreted in urine

The two cysteine residues form a disulfide bond, creating a cyclic structure that enhances stability

Intramuscular (IM) injections are typically administered into the arm's deltoid muscle, the vastus lateralis muscle of the thigh, or the ventrolateral muscle of the hip

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Farmacotherapeutisch Kompas, (pharmaceutical reference book) Amstelveen