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Spontaneously formed methemoglobin is normally reduced (regenerating normal hemoglobin) by protective enzyme systems, e.g., NADH methemoglobin reductase (cytochrome-b5 reductase) (major pathway), NADPH methemoglobin reductase (minor pathway) and to a lesser extent the ascorbic acid and glutathione enzyme systems

10.1093/jexbot/52.363.1959 J

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S-Acetyl is most effective when administered at 200 milligrams per capsule, a transparency in formulation that Nuwhite has been proud of for years