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Genetic variations in the MTR and MTRR genes can alter enzyme activity, increasing risks for schizophrenia, cognitive impairment, and heart disease due to disrupted homocysteine and methionine levels

You can get vitamin B12 from certain foods (such as meat, fish, eggs, or dairy products)

doi: 10.3389/fendo.2026.1822475 Received 03 March 2026 Revised 05 May 2026 Accepted 02 June 2026 Published 18 June 2026 Volume 17 - 2026 Edited by Carmine Bruno, Link Campus University, Italy Reviewed by Matej Rakusa, University Medical Centre Ljubljana, Slovenia Fredrik Tiberg, Camurus AB, Sweden Updates Copyright 2026 Dominikowski, Rko, Olejarz, Szczepanek-Parulska, Domin and Ruchaa

However, individuals with certain conditions should exercise caution

By blocking NNMT activity, the compound preserves nicotinamide availability for the NAD+ salvage pathway, leading to 1.2- to 1.6-fold increases in intracellular NAD+ concentrations