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[12] Use is contraindicated in individuals with a known hypersensitivity to tretinoin, azelaic acid, niacinamide, or any excipient, and in those with active eczematous dermatitis or facial sunburn until healing occurs

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Indeed, HPV-positive cervical cancer exhibits distinct metabolic reprogramming, involving increased glycolysis, purine salvage, and glutathione metabolism 8

Studies have also revealed a possible nonlinear link between dietary folate consumption and the risk of breast cancer