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Ovothiol, a marine-derived 5(N)-methyl-thiohistidine, is a more effective non-competitive-like GGT inhibitor than traditional counterparts such as acivicin, 6-diazo-5-oxo-norleucine and azaserine (105,161)

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Such Sirts have the potential to downregulate the NF-B pathway, which helps reduce neuroinflammation (Paxinou et al., 2001) Sirt2 has been reported to deacetylate NOD-like receptor pyrin domain containing 3 (NLRP3) and prevent aging-related chronic inflammation (Li et al., 2021), while Sirt3 inhibits NLRP3 by reducing mitochondrial damage and mtDNA release (He et al., 2020)

The stained sections were photographed using an Olympus CX41 light microscope in bright field mode and an Olympus SC100 digital camera

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