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Edited by: Kramer K, Hoppe PP, Packer L

Review FRAT testing Screen the Pattern, Then Confirm Undermethylation and Mitochondrial Stress With Testing Symptoms can suggest possible undermethylation or mitochondrial stress, but laboratory findings help distinguish low SAM, elevated SAH, oxidative damage, copper-zinc imbalance, pyroluria and functional nutrient needs

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Its efficacy is thought to be due to a reduction in collagen formation via decreasing serotonin levels, increasing monoamine oxidase activity, and inhibiting fibroblast glycosaminoglycan secretion (6)