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Saghazadeh A, Rezaei N (2017) Systematic review and meta-analysis links autism and toxic metals and highlights the impact of country development status: higher blood and erythrocyte levels for mercury and lead, and higher hair antimony, cadmium, lead, and mercury

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R When the methylation cycle is impaired (MTHFR variants, B12/folate deficiency, BH4 depletion), SAH accumulates and inhibits COMT, HNMT, and other methyltransferases simultaneously

doi: 10.1111/j.1365-3156.2008.02187.x

This group of cells is often implicated in inflammatory and degenerative disorders of the brain ( Classically the study of demyelination in disease has focused on oligodendrocytes, as those cells are primarily affected, but recent literature has shown an emerging role of other glial cells, particularly astrocytes and microglia, in regulating not only myelination but also neuroinflammation and neuroplasticity in the course of the disease ( As different mechanisms at a cellular level may be the cornerstone of developing more accurate biomarkers and effective DMTs, it is imperative to study the different influences which glial cells may exert in primary demyelinating phenotypes