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As an alternative strategy to identify the best overlap, we analyzed the relationship between ion transmission and centerness, where the transmission is defined as the relation between the intensity of the extreme m / z compared to the intensity of the centermost precursor for DIA windows in two consecutive scan cycles shifted by half-a-window

The lowest-energy conformer for each calculated stationary (available in PDB format as Supplementary Figs

Beyond its canonical role in hypoxia signaling, HIF-1 integrates hypoxic responses with other environmental and metabolic signaling pathways (53, 54)

Atomic coordinates have been deposited in the Protein Data Bank (PDB) under accession codes 9PMD (OCTN2 inward-facing), 9PDQ (OCTN2 occluded) and 9PFB (OCTN2 ipratropium)