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First, although SLC30A10 mediates the release of Mn from the brain and SLC39A8 facilitates its uptake 312 , the precise mechanisms that regulate neuronal Mn transport and accumulation remain poorly understood

Presumably, oxidative stress is involved in the pathogenesis and complications associated with all three types of DM, and GPx1 plays a critical role in the regulation of oxidative stress [60]

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In glaucoma, the increased levels of A, p-tau, and amyloid precursor protein initiate an inflammatory response, leading to cytokine secretion and iron overload

FIGURE 8 4 Conclusion In summary, a novel RBC-coated biomimetic self-cascade bioreactor (RBC@SeMSN@Uri) was designed and synthesized for the treatment of hyperuricemia and gout