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Astrocytes are highly responsive glial cells that interact with immune and neural cells and become activated when encountered with any foreign insult, including chronic injuries, infections, acute trauma and neurodegenerative diseases 20

Melatonin suppresses LTP via the MT2 receptors, as reported by Liu et al

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Recombinant human active caspase-3, human WT, C45A, C180A, C371A His-sumo-GSDME-eGFP were from BioGot (Nanjing, China), recombinant human His-GSDME (CSB-EP006766HU) was from CUSABIO (Wuhan, China), recombinant human active caspase-4 was purchased from Biovision (1084-100, San Francisco, USA), recombinant human His-sumo-GSDMD-eGFP, His-sumo-GSDME were from Detai Bio (Nanjing, China), recombinant human TNF (300-01 A) was purchased from Peprotech (Cranbury, USA), recombinant perforin/PFR (APB317Hu02) was purchased from Cloud-Clone (Wuhan, China), recombinant granzyme B/GZMB (HY-P75157) was purchased from MCE (NJ, USA)

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